Stem cell reprogramming pioneer. Creator of synthetic embryo systems. Former RIKEN / Yamanaka Lab scientist delivering cutting-edge biotech solutions. Former Director of R&D for Trans Ova Genetics, a world leader in livestock reproduction technologies.
World-class stem cell biologist and former investigator at RIKEN Center for Biosystems Dynamics Research. Trained in the Nobel Prize-winning Yamanaka Lab and the lab of revolutionary pioneer Masayo Takahashi MD PhD. Pioneer in induced totipotency, synthetic embryogenesis, novel reprogramming system design/development, and game-changing livestock technologies.
Dr. Kime has spent over 15 years pushing the boundaries of cellular reprogramming. His groundbreaking work on stem-cell-derived blastocyst-like structures and totipotent reprogramming continues to influence regenerative medicine, organoid technology, and agricultural biotechnology.
First stem-cell-derived structures mimicking early embryonic development (Stem Cell Reports, 2019 & 2021).
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Advanced protocols converting primed pluripotent cells to totipotent-like states with functional trophoblast potential.
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Optimized footprint-free reprogramming + full transcriptomic atlas at any stage.
View Full Paper βMicroscopy, single-cell data, and synthetic embryo visuals from Dr. Kimeβs peer-reviewed work
Figure 1 β’ iBLC induction overview (2019)
Stem Cell Reports β
Figure 4 β’ Marker comparison: iBLC vs BC (2019)
Stem Cell Reports β
Figure 1 β’ scRNA-seq time course (2021)
PMC8185450 β
Figure 2 β’ 2C-like state & trophoblast lineage (2021)
Stem Cell Reports β
Stem Cell Reports β’ Kime et al.
Rapid and efficient induction of patient-specific cells for macular degeneration
Media based touchless induction of Naive Pluripotency
Specialized in ideation and development of new cell reprogramming systems.
Development and use of integrated bioinformatics analyses, from cell to data to analysis to visualization and interpretation.
Significant IP filing experence and patent holding across various countries and technologies.
Conceptualization and deployment of novel strategies for livestock genesis.
All lab media, protocols, and datasets are available exclusively through consulting engagements.
Email Dr. Kime β’ [email protected]